Global, regional, and national trends in drug use disorder mortality rates across 73 countries from 1990 to 2021, with projections up to 2040: a global time-series analysis and modelling study.

EClinicalMedicine · 2025 · PMC11720110 · PMID 39802307

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an increasing trendno p-value reported

Interpretation An increasing trend in global DUD mortality was observed from 1990 to 2021, especially in HICs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.