Efficacy of tranilast in preventing exacerbating cardiac function and death from heart failure in muscular dystrophy patients with advanced-stage heart failure: a single-arm, open-label, multicenter study.

Although a slightly increasing trend in renal indices was observed, this phenomenon was due to cardiorenal syndrome, which is naturally observed in patients with MD and advanced heart failure [ 18 , 19 ].

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Subsequently, there was an increasing trend, but the 95% CI for the rate of change from baseline included 0, except at 144 weeks (Fig. 3 a).

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