Cascading expression of ApiAP2 transcription factors controls daughter cell assembly in Toxoplasma gondii.

Upon analyzing the differential enrichment between upregulated and downregulated transcripts encoding proteins localized to specific organelles in the parasites using the HyperLOPIT dataset from Barylyuk et al (2020) [ 31 ], we identified a notable trend: a significant proportion of the upregulated transcripts encode proteins that localize to the Rhoptries (5.7% of upregulated transcripts in the HyperLOPIT dataset; Fig 3E ) compared to 0.9% of downregulated transcripts ( Fig 3E and 3G ), the apical compartment (4.2% of upregulated transcripts in the HyperLOPIT dataset; Fig 3E ) compared to 1.8% of downregulated transcripts ( Fig 3G ), and the IMCs (4.2% of upregulated transcripts in the HyperLOPIT dataset; Fig 3E ) compared to 1.8% of downregulated transcripts ( Fig 3G ).

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