In-depth inference of transcriptional regulatory networks reveals NPM1 as a therapeutic ribosomal regulator in MYC-amplified medulloblastoma.

NPJ Precis Oncol · 2025 · PMC11723958 · PMID 39794402

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

borderline significanceP = 5.8e-02so close (0.05 < p ≤ 0.1)

The RB signature was significantly correlated with an increased risk of 15% in the continuum (HR = 1.15, P = 1.1e-05), whereas the G3γ subtype exhibited the highest hazard ratio among all subtypes with borderline significance (HR = 2.55, P = 5.8e-02; Fig. 2e ).

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