Point mutations in functionally diverse genes are associated with increased natural DNA transformation in multidrug resistant Streptococcus pneumoniae.

Of note, a mutation in cpsR (SPV_0064; cpsR V68I ), one of the two transcription factors repressing capsule biosynthesis in the airways ( 42 ), was highly significant (lrt P -value 2.4 × 10 −19 ) in GWAS-2 ( Supplementary Table S6B ).

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