RhoG-Rac1 Signaling Pathway Mediates Metabolic Dysfunction of the Pancreatic Beta-Cells Under Chronic Hyperglycemic Conditions.

Cell Physiol Biochem · 2021 · PMC11724327 · PMID 33851799

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may be significantno p-value reported

This observation may be significant in the context of Rac1-mediated beta-cell dysfunction under these conditions in that we have recently demonstrated a significant degree of association of Rac1 with the nuclear fraction (mislocalization or mistargeting) in INS-1 832/13 cells, normal rat islets and human islets exposed to glucotoxic conditions [ 24 ].

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