CF₂H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines.

pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement yes pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY-NC-ND issue-copyright-statement © Springer Nature Limited 2025 Introduction Organofluorine chemistry has emerged as a highly significant field over the past few decades, enabling the on-demand synthesis of a wide range of unnatural fluorinated molecules, which has garnered considerable research interest, particularly in pharmaceuticals, agrochemicals, and specialized materials 1 – 12 .

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