Circulating Adenoid Cystic Carcinoma associated MYB transcripts enable rapid and sensitive detection of metastatic disease in blood liquid biopsies.

The area under the curve (AUC) for both ROC curves were 0.9825 and 0.9352, respectively, indicating a highly significant and sensitive test ( Fig. 1 C and D). 3.2 Circulating tumor cells (CTCs) are the source of elevated MYB in metastatic ACC blood To elucidate the source of the elevated MYB signal detected in metastatic ACC blood samples, we isolated RNA from the plasma and mononuclear cell (PBMC) fractions to determine if the MYB signal arose from cell-free (plasma) or cell based (PBMCs) RNA sources.

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