Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.

Biomolecules · 2024 · PMC11727524 · PMID 39766343

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0623

boldest claim

The sentences

a decreasing trendp < 0.05actually significant

Gene expression analysis of MMP-13 showed an increase in the H 2 O 2 group (inhibitor-/H 2 O 2 +) and a decreasing trend in the treatment groups, with a significant decrease observed in the combination group (H 2 O 2 +/Celecoxib+/Tocilizumab+) ( p < 0.05) ( Figure 4 d). 3.4.

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an increasing trendp = 0.0623so close (0.05 < p ≤ 0.1)

Nrf2 gene expression showed an increasing trend in the combination group (H 2 O 2 +/Celecoxib+/Tocilizumab+) compared with that in the H 2 O 2 group (H 2 O 2 +/inhibitor-) ( p = 0.0623) ( Figure 5 d).

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