Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains' Inflammatory Profiles.

As expected, and similar to our data in APOE4 primary microglia, PLIN2 protein content in the forebrain of the nanoparticle F12511 -treated group exhibited a decreasing trend compared to the PBS-treated group in both APOE3 and APOE4 mice, suggesting a reduction in neutral lipid droplet content in the brains of these mice.

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