Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis.

Osteoarthr Cartil Open · 2025 · PMC11728867 · PMID 39807424

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a positive trendno p-value reported

Another RCT of 64 persons with erosive hand OA showed a positive trend with larger pain relief in patients treated with methotrexate versus placebo after 3 months, but the difference between groups was not statistically significant.

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