In vivo imaging of mitochondrial function in normal, glaucoma suspect, and glaucoma eyes.

The device does not measure the total number of mitochondria within a specific retinal layer; to address this limitation and the potential impact of a reduced number of mitochondria or dysfunctional mitochondria in OAG, we calculated a ratio of FPF intensity by dividing FPF scores by the global RNFL thickness, which serves as a surrogate for the total number of mitochondria in the RNFL layer, but we found no significant differences between FPF metrics among the groups, though ONH FPF mean score/RNFL thickness was found to be borderline significant.

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While normal and glaucoma suspects had significantly thicker RNFL and GCIPL thickness compared to glaucoma in our multiple comparison analysis, the P values were highly significant for RNFL thickness but only borderline significant for GCIPL after Bonferroni adjustment.

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