A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.

Diabetologia · 2025 · PMC11732898 · PMID 39579208

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borderline significanceno p-value reported

to <10 years’ group had an adjusted HR of 1.62 (95% CI 1.04, 2.53, p =0.033) and 1.52 (95% CI 1.02, 2.27, p =0.040) for CKD and cardiovascular–kidney disease, respectively, while the ‘top-20%-wPRS plus baseline DD<5 years’ group had an adjusted HR of 1.63 (95% CI 0.93, 2.87, p =0.089) for CVD, with borderline significance.

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