Strong Association Between HIV Incidence and Herpes Simplex Virus Type 2 in Zambia and South Africa: Prospective Data From the HPTN 071 (PopART) Trial.

Open Forum Infect Dis · 2025 · PMC11733628 · PMID 39817038

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highly significantno p-value reported

Consistent with previous evidence from a meta-analysis [ 2 ], we found highly significant associations in both sexes, with a roughly 3-fold increase in incidence in those who were already HSV2 positive at baseline and a stronger 6- to 8-fold increase in those who seroconverted to HSV2 during the trial.

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