The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta-Analysis.

JGH Open · 2025 · PMC11735734 · PMID 39822339

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a positive trendno p-value reported

Additionally, the United States Food and Drug Administration approved lubiprostone (24 μg twice daily) for CIC after a positive trend was observed favoring lubiprostone over placebo in two randomized double‐blind placebo‐controlled clinical trials consisting of 479 patients [ 35 ].

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