Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity.

Discrimination models were examined using OPLS-DA, revealing highly predictive (Q2 > 0.63) and highly significant ( p < 0.0001) differences between sTBI patients and OI controls using metabolic profiles obtained by DI/LC–MS/MS and 1 H-NMR on day 4 post-injuries (Fig. 1 ).

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