A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models.

Nat Biotechnol · 2025 · PMC11738990 · PMID 38459338

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a decreasing trendno p-value reported

Treatment with the INS018_055–pirfenidone combination (3 mg per kilogram body weight (mpk) by mouth (p.o.), BID + 60 mpk, p.o., BID) significantly decreased the modified Ashcroft score, fibrotic lung area (Masson’s trichrome staining) and α-SMA abundance as compared with vehicle treatment of mice, while a decreasing trend of collagen I was also observed (Extended Data Fig. 8c,d ).

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