borderline significantp = 0.05
There was a borderline significant protective effect observed in the dominant Caucasian model (OR = 0.65, p = 0.05), with no heterogeneity (I 2 = 0%), indicating that the studies were consistent in their findings. 3.1.2 Soluble RAGE The secreted isoform of RAGE, termed soluble RAGE (sRAGE) was found to be released from cells to bind to RAGE ligands without stimulating intracellular signal transduction.