Estimating myocardial fibrosis in aortic stenosis using the serum collagen type I C-terminal telopeptide to matrix metalloproteinase-1 ratio.

Importantly, we discovered a trend for a negative association between the level of histological MF and serum CITP:MMP1 ratios in the cohort as a whole ( r = −0.18; p = 0.08), which could predominantly be attributed to the highly significant association in the classical LF‐LG AS group ( r = −0.62; p = 0.002) (Figure 1C,D ).

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