In this organoid, we observed some less common epicardium-fate marker genes that show an increasing trend with differentiation, such as SEMA3D , ALDH1A2 , UPK3B [ 20 ], PDGFRA (Fig. 1 E) as an evidence of epicardium development.
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Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation.
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