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Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner.

Mol Biol Cell · 2025 · PMC11742114 · PMID 39630611

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Furthermore, although the total % of TRAP-positive cells (∼95–98%) of the RANKL-stimulated group was not enhanced by the addition of CM derived from control shRNA-expressing tumor cells, we noted an increasing trend in the ratio of OCL-to-OCLp pool ( Figure 2C ).

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