Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease.

We also created protein interaction networks of non-plaque tissue DS, EOAD, and LOAD proteomes, which showed a highly significant degree of protein–protein interactions (PPI enrichment p = 1 × 10 −16 , Supp.

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For instance, 35 proteins that were significantly enriched proteins detected in the Drummond study but not significant in ours were nonetheless observed in our dataset, with many showing increased abundance trends that nearly reached significance.

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