Identification and Characterization of Genes Associated with Intestinal Ischemia-Reperfusion Injury and Oxidative Stress: A Bioinformatics and Experimental Approach Integrating High-Throughput Sequencing, Machine Learning, and Validation.

Genes that were co-expressed across all four methodologies were subsequently recognized as the final set of highly significant HIOSRGs.

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Subsequent PCR and immunohistochemistry analyses of HIOSRGs demonstrated an increasing trend in ABCG2 and ALDH18A1, and a decreasing trend in CYP1A2 and HDAC3 in the intestinal tissue of IIRI mice compared to Sham group mice ( Figure 7C-N ) ( Figure 8A-D ), thereby affirming the reliability of HIOSRGs through in vivo experiments.

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