The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking.

Mol Psychiatry · 2025 · PMC11746135 · PMID 39227431

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Additionally, we found that C4-OE caused a significant decrease in the quantity of GluR1 clusters colocalizing with Rab11a, while the number of Rab11a-positive clusters associating with GluR1 showed a decreasing trend without reaching significance (Fig. 4D, E ).

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