Paradoxical dominant negative activity of an immunodeficiency-associated activating <i>PIK3R1</i> variant.

Also in keeping with previous reports ( Chudasama et al., 2013 ; Dornan et al., 2017 ; Dornan et al., 2020 ), p85α R649W showed severely reduced phosphotyrosine-stimulated activity in complex with p110α, with highly significant but lesser loss of function seen for Y657X and E489K ( Figure 3A , Figure 3—figure supplement 1A ).

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