Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration.

We found a highly significant and marked response of control neurons to 100 nM orexin A, while the Ox1R knockout neurons did not respond (control: p<0.0001, n=71; Ox1R ΔDAT : p=0.5, n=86; one sample t-test for each group) ( Figure 1L ).

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