Barely Significant
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Management of Patients With Refractory Reflux-Like Symptoms Despite Proton Pump Inhibitor Therapy: Evidence-Based Consensus Statements.

Aliment Pharmacol Ther · 2025 · PMC11754941 · PMID 39740235

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marginally statistically significantp = 0.05actually significant
Meta‐analysis of four RCTs ( N = 1425) in patients with rGERD showed a marginally statistically significant ( p = 0.05) increase in the symptom response rate when a TLESR inhibitor was added to PPI therapy compared to PPI therapy alone (RR, 0.93; 95% CI, 0.86–1.00) [ 72 , 73 , 74 , 75 ].

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