Global, regional, and national burden of heart failure and its underlying causes, 1990-2021: results from the global burden of disease study 2021.

Biomark Res · 2025 · PMC11755835 · PMID 39849627

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an increasing trendno p-value reported

Research has found that over the past 30 years, the burden of ischemic heart disease has shown an increasing trend in the population aged 80 and above.

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a positive trendno p-value reported

The improvement in HF treatment methods has extended patients’ survival periods, and while this is a positive trend, it also means that more patients survive for longer periods, thereby increasing the overall disease burden [ 25 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.