Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization.

Of note, images taken within the final 12 h appear similar which may indicate a pseudo-steady state during which MIN6 hypoxic cell death no longer occurs and cell expansion is not yet significant, as further substantiated by the quantified fluorescent signal plateau at the 30-h mark ( Figure 4(d) ).

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