highly significantp < 0.01
administration of the CTA1-I/II-aCD103 vaccine both conferred highly significant ( p < 0.01 for both, n = 5 mice per group, ANOVA) and almost complete protection from metastasis (3/5 metastasis-free mice following i.n. vaccination and 5/5 metastasis-free mice after i.p. vaccination 12 ), indicating that local and systemic administrations of the vaccine are equally effective in preventing metastasis formation by OVA-expressing tumor cells.