Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer's Disease.

This considerable disruption of the β -sheet-rich core was accompanied by conformational alterations toward helical structures, an increasing trend in structural deviations (RMSD plot), increased residue flexibility (RMSF analysis), and structural expansion of the oligomeric structure (Rg analysis), highlighting its ability to destabilize the A β oligomer architecture, a vital step toward inhibiting amyloid fibril formation.

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