Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy.

Cell Death Discov · 2025 · PMC11762734 · PMID 39863573

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a decreasing trendno p-value reported

In NMJs with SOD1 D90A MNs, the MN volume significantly decreased to 60.44% ± 7.41%, while the MN-to-SKM ratio exhibited a decreasing trend to 64.44% ± 12.29%, though this reduction was not statistically significant (Fig. 7C , D ).

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