A Novel, Cell-Compatible Hyaluronidase Activity Assay Identifies Dextran Sulfates and Other Sulfated Polymeric Hydrocarbons as Potent Inhibitors for CEMIP.

Although flavonoids such as ipriflavone have been proposed as CEMIP hyaluronidase inhibitors [ 17 , 36 ], ipriflavone did not inhibit the CEMIP hyaluronidase activity in our assay, likely because higher concentrations that those we employed here are required to achieve partially significant inhibitory effects [ 36 ], suggesting that ipriflavone is a relatively weak CEMIP inhibitor.

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