Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway.

Cell Biosci · 2025 · PMC11765919 · PMID 39863890

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a decreasing trendno p-value reported

Downregulation of AKT phosphorylation (p-AKT S473 ) was not only observed in WRN-KD MSC, but also in serially passaged normal MSC, in which WRN protein showed a decreasing trend when the cells had accumulated replication (Fig. 1 b).

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