Preventive Effects of Botulinum Neurotoxin Long-Term Therapy: Comparison of the 'Experienced' Benefits and 'Suspected' Worsening Across Disease Entities.

Patients with migraines (MIG-group in Table 1 ) were all females, had the youngest age (53.0 years in the mean), had the longest time to therapy (24 years in the mean!), were exclusively treated with onabotulinumtoxin (onaBoNT/A), and reported the best highly significant ( p < 0.0001) relative mean improvement (100 − (RS-%)) of more than 65% and suspected only a mild non-significant ( p > 0.05) further worsening ((SS-%) − 100 = SWORS-%) of less than 10% in the mean beyond the level of severity at onset of BoNT therapy.

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