Multiple Gene Deletion Mutants of Equine Herpesvirus 1 Exhibit Strong Protective Efficacy Against Wild Virus Challenge in a Murine Model.

The antibody levels progressively increased with a subsequent booster dose, and all three immunized groups showed a highly significant ( p < 0.0001) elevation in OD values compared to the unvaccinated mice at 35 dpv (OD values: 1.38 ± 0.00, 1.23 ± 0.01, and 0.91 ± 0.01 for vToH-QMV, vToH-DMV, and wt, respectively) ( Figure 3 B, Table S3 ).

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