Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules.

Specifically, we estimated in silico the predicted binding affinity of anthrax vaccine antigen (PA) epitopes to the HLA-II molecules present in a large sample of Gulf War veterans and documented a highly significant negative association between the strength of binding affinity of PA epitopes to HLA-II molecules and GWI symptom severity.

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