Emerging Pharmacological Approaches for Psychosis and Agitation in Alzheimer's Disease.

CNS Drugs · 2025 · PMC11769872 · PMID 39623197

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a positive trendno p-value reported

A post hoc analysis of a negative study on mirtazapine in 218 patients with depression suggested a positive trend in reducing median NPI scores [ 70 ], but in the 12-week SYMBAD study, mirtazapine (up to 45 mg/day) did not reduce agitation (measured with CMAI score) [ 71 ].

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a nonsignificant trendno p-value reported

On the CGI-S scale, the 2 mg/day dose showed a nonsignificant trend compared with the placebo group.

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