Quantifying the ability of the CF<sub>2</sub>H group as a hydrogen bond donor.

Beilstein J Org Chem · 2025 · PMC11773185 · PMID 39877859

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an expected trendno p-value reported

Our experiment with neutral HB donors reproduced literature results ( Table 1 , compounds 10 , 11 , and 12 ) [ 20 , 22 , 47 ] and revealed an expected trend in HB donation ability; for example, compound 1a is a weaker HB donor than 3a .

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