A conserved element in the first intron of <i>Cd4</i> has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent lineage choice error.

At the CD4SP stage, we found barely significant NCE enhancer function in the murine EL-4 CD4SP lymphoma cell line with the NCE1F, but not with the NCE1Fx2, even though the proximal enhancer was still functional ( Figure 2C ), indicating that NCE’s canonical enhancer function may diminish in mature CD4SP T cells.

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