Axonal Organelle Buildup from Loss of AP-4 Complex Function Causes Exacerbation of Amyloid Plaque Pathology and Gliosis in Alzheimer's Disease Mouse Model.

This exacerbation of amyloid plaque pathology was region specific as the plaque size and abundance measured in the cerebral cortex did not show an increase upon loss of AP-4 complex, but in fact a slight trend toward decrease (Extended Data Fig. 1-3 ).

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