Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling.

Redox Rep · 2025 · PMC11776066 · PMID 39874130

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Furthermore, after 4-HC induced, the content of ferrous iron was obviously increased and those in all administration group showed a decreasing trend ( P <0.05), especially in the SCM group ( P <0.05, Figure 4 D), indicating that the treatment of salidroside, CM and SCM inhibited the mitochondrial membrane potential decrease and ferrous iron increase of GCs induced by 4-HC in vitro.

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