SARS-CoV-2 CoCoPUTs: analyzing GISAID and NCBI data to obtain codon statistics, mutations, and free energy over a multiyear period.

Virus Evol · 2025 · PMC11776705 · PMID 39882309

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an interesting trendno p-value reported

This revealed an interesting trend of reduced ensemble free energy compared to the unaltered variant structures, indicating that synonymous mutations play a role in increasing the free energy of viral RNA molecules.

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