Barely Significant
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Transition from hypothyroidism to Graves' disease, development of thyroid eye disease, progression to optic neuropathy after inpatient pulse therapy, and long-term administration of outpatient pulse therapy: a case report with review of literature.

Endocr J · 2025 · PMC11778384 · PMID 39322555

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a positive trendno p-value reported
If there is a positive trend in vision restoration, treatments such as additional pulse therapy and/or orbital irradiation therapy should be continued; however, the total dose of MP should be limited to <8 g because of the potential for severe liver toxicity [ 4 - 7 ].

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