ZBTB24 peaks showed a highly significant enrichment of the 5′-CAGGACCT-3′ DNA motif (E_value = 2.8e-34) ( Fig. 1A , lower panel), identical to the one identified for a FLAG-tagged ZBTB24 protein in the colon cancer cell line HCT116 [ 23 ].
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ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats.
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