Prediction of long-term drug-free outcomes in ACPA-positive and ACPA-negative rheumatoid arthritis by combined clinical and ultrasound assessment of residual disease: a 5-year prospective study.

Predictors of flare in the whole population Whole population multivariable Cox regression model, including selected variables from each analytical dimension ( table 2 ) and corrected for sex and age at the time of MTX withdrawal, confirmed the highly significant effect of the serological status (ACPA positivity) (HR: 4.20; 95% CI 2.37 to 7.44; p<0.0001) on the prediction of time-to-flare as previously observed in independent and more heterogeneous cohorts.

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