Downregulation of PGAM2 alleviates angiotensin II-induced cardiac hypertrophy by destabilizing HSP90 and inactivating the mTOR/IKKα signaling pathway.

Int J Biol Sci · 2025 · PMC11781161 · PMID 39897023

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an increasing trendno p-value reported

Additionally, in a proteomic analysis on effluents from perfused human hearts, the concentration of PGAM2 showed an increasing trend when the ischemic time was extending, suggesting its potential as a diagnostic and therapeutic biomarker for myocardial ischemia 4 .

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