Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.

More specifically, in this process, we first observed macrophages infiltration, along with the expression of CCL2 and ICAM-1, VCAM-1, which are essential in recruiting macrophages and mediating macrophages adhesion to endothelial cells, showed an increasing trend in obese WT mice and MT -KO mice with ND, and a significant increase in MT -KO obese mice.

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We initially observed a decreasing trend in Zn levels in MT- KO obese mice compared to their counterparts on a ND, although this difference was not statistically significant.

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