The value p < 0.05 was considered to indicate a significant difference, and p < 0.01 indicated an extremely significant difference. 3 Results 3.1 VASN knockout induces MF HE staining showed that the thickness of the heart wall in a VASN −/− mouse was significantly higher than those in VASN +/+ and VASN +/− mice ( Figures 1A, E2 ).
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VASN knockout induces myocardial fibrosis in mice by downregulating non-collagen fibers and promoting inflammation.
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