Sex-related differences in the prognostic utility of inflammatory and thrombotic cardiovascular risk markers in patients with chest pain of suspected coronary origin.

All-cause mortality and composite endpoint in acute MI patients at 7 years follow-up In patients with an acute MI (TnT release > 50 ng/L) at baseline, unadjusted SERPINA3 was significantly associated with all-cause mortality only in males at 7 years follow-up, but the association was weakened and borderline significant (p = 0.051) in the multivariable analysis, and presented with a non-significant p-value for interaction between the biomarker and sex (p = 0.17) ( Supplementary Table 3 ).

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Only SERPINA3 was found to predict all-cause mortality limited to the male population with an acute MI at index admission, reaching borderline significance (multivariable model, p = 0.051) despite the presence of an acute phase reaction which is bound to mask its utility as a prognostic marker.

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Interestingly, SERPINA3 exerted a highly significant prognostic impact in the non-AMI male population, which is relevant to patients with acute chest pain of suspected coronary origin and no definite AMI, even in the era of high-sensitivity assays.

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